snp genotypes by principal component analysis (pca) and by the pairwise fixation index Search Results


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Genotype and allele frequencies of <t> AGO1 </t> and AGO2 genes
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Distribution of <t> C1QA/C1QB </t> genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).
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Distribution of <t> C1QA/C1QB </t> genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).
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Distribution of <t> C1QA/C1QB </t> genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).
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Distribution of <t> C1QA/C1QB </t> genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).
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Distribution of <t> C1QA/C1QB </t> genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).
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Image Search Results


Genotype and allele frequencies of  AGO1  and AGO2 genes

Journal: American Journal of Translational Research

Article Title: The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients

doi:

Figure Lengend Snippet: Genotype and allele frequencies of AGO1 and AGO2 genes

Article Snippet: Real-time Polymerase Chain Reaction was performed in the StepOne™ Real-Time PCR System (Applied Biosystems, USA) using TaqMan Genotyping PCR Master Mix, No UNG (4440043), and TaqMan SNP Genotyping Assay Mix (assay ID C___1079151_10 for rs636832 and C___9176197_10 for rs2977490, Thermo Fisher Scientific).

Techniques: Variant Assay

Genetic association models for disease risk assessment

Journal: American Journal of Translational Research

Article Title: The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients

doi:

Figure Lengend Snippet: Genetic association models for disease risk assessment

Article Snippet: Real-time Polymerase Chain Reaction was performed in the StepOne™ Real-Time PCR System (Applied Biosystems, USA) using TaqMan Genotyping PCR Master Mix, No UNG (4440043), and TaqMan SNP Genotyping Assay Mix (assay ID C___1079151_10 for rs636832 and C___9176197_10 for rs2977490, Thermo Fisher Scientific).

Techniques:

In silico data analysis on AGO1 and AGO2. (A, B) Cellular localization of AGO1 and AGO2 proteins showing widely spread of the proteins within the cytosol and the nucleus. Data source: Compartment (https://compartments.jensenlab.org/) which integrates evidence from manually curated literature, high-throughput screens, automatic text mining, and sequence-based prediction methods. (C) Genetic alterations of AGO1 and AGO2 of 8874 breast cancer patients in 15 studies. Studies were retrieved from cBioportal for Cancer Genomics (www.cbioportal.org). After combination, the frequency and type of AGO1 and AGO2 genetic alterations were calculated. Both somatic mutations and copy number variations were screened. (D, E) Kaplan-Meier curve of 3591 breast cancer patients showing poor survival of breast cancer patients with low AGO1 gene expression and high AGO1 expression profile. Expression level is split by the median. Number of included patients is displayed below the figure. Data source: Kaplan-Meier Plotter (https://kmplot.com/analysis/index.php?p=service).

Journal: American Journal of Translational Research

Article Title: The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients

doi:

Figure Lengend Snippet: In silico data analysis on AGO1 and AGO2. (A, B) Cellular localization of AGO1 and AGO2 proteins showing widely spread of the proteins within the cytosol and the nucleus. Data source: Compartment (https://compartments.jensenlab.org/) which integrates evidence from manually curated literature, high-throughput screens, automatic text mining, and sequence-based prediction methods. (C) Genetic alterations of AGO1 and AGO2 of 8874 breast cancer patients in 15 studies. Studies were retrieved from cBioportal for Cancer Genomics (www.cbioportal.org). After combination, the frequency and type of AGO1 and AGO2 genetic alterations were calculated. Both somatic mutations and copy number variations were screened. (D, E) Kaplan-Meier curve of 3591 breast cancer patients showing poor survival of breast cancer patients with low AGO1 gene expression and high AGO1 expression profile. Expression level is split by the median. Number of included patients is displayed below the figure. Data source: Kaplan-Meier Plotter (https://kmplot.com/analysis/index.php?p=service).

Article Snippet: Real-time Polymerase Chain Reaction was performed in the StepOne™ Real-Time PCR System (Applied Biosystems, USA) using TaqMan Genotyping PCR Master Mix, No UNG (4440043), and TaqMan SNP Genotyping Assay Mix (assay ID C___1079151_10 for rs636832 and C___9176197_10 for rs2977490, Thermo Fisher Scientific).

Techniques: In Silico, High Throughput Screening Assay, Sequencing, Expressing

Functional enrichment analysis of AGO1 and AGO2. (A) AGO1 and AGO2 are involved in various cancer hallmarks. Comparison between the functional role of AGO1 and AGO2 in cancer. Cancer Hallmarks Analytics Tool (CHAT) was used (http://chat.lionproject.net). It is a text mining approach that organizes and evaluates scientific literature on cancer. They showed various alterations in cell behavior in cancer state. (B) Gene-gene network analysis revealing interaction of AGO1 and AGO2 with various cancer-related genes and microRNA machinery component pathway genes. Data source: GeneMania (GeneMania.org). (C) Protein-protein network using STRING version 11.0 (https://string-db.org/) showing significant biological processes enriched in tumorigenesis as senescence, angiogenesis, and cell differentiation.

Journal: American Journal of Translational Research

Article Title: The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients

doi:

Figure Lengend Snippet: Functional enrichment analysis of AGO1 and AGO2. (A) AGO1 and AGO2 are involved in various cancer hallmarks. Comparison between the functional role of AGO1 and AGO2 in cancer. Cancer Hallmarks Analytics Tool (CHAT) was used (http://chat.lionproject.net). It is a text mining approach that organizes and evaluates scientific literature on cancer. They showed various alterations in cell behavior in cancer state. (B) Gene-gene network analysis revealing interaction of AGO1 and AGO2 with various cancer-related genes and microRNA machinery component pathway genes. Data source: GeneMania (GeneMania.org). (C) Protein-protein network using STRING version 11.0 (https://string-db.org/) showing significant biological processes enriched in tumorigenesis as senescence, angiogenesis, and cell differentiation.

Article Snippet: Real-time Polymerase Chain Reaction was performed in the StepOne™ Real-Time PCR System (Applied Biosystems, USA) using TaqMan Genotyping PCR Master Mix, No UNG (4440043), and TaqMan SNP Genotyping Assay Mix (assay ID C___1079151_10 for rs636832 and C___9176197_10 for rs2977490, Thermo Fisher Scientific).

Techniques: Functional Assay, Cell Differentiation

Multiple regression analysis for the role of  AGO1  and AGO2 variants in disease outcomes

Journal: American Journal of Translational Research

Article Title: The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients

doi:

Figure Lengend Snippet: Multiple regression analysis for the role of AGO1 and AGO2 variants in disease outcomes

Article Snippet: Real-time Polymerase Chain Reaction was performed in the StepOne™ Real-Time PCR System (Applied Biosystems, USA) using TaqMan Genotyping PCR Master Mix, No UNG (4440043), and TaqMan SNP Genotyping Assay Mix (assay ID C___1079151_10 for rs636832 and C___9176197_10 for rs2977490, Thermo Fisher Scientific).

Techniques:

 Components  and volume of the PCR reactions.

Journal: Biomedicines

Article Title: Reliable and Fast Genotyping Protocol for Galactosylceramidase (Galc) in the Twitcher (Twi) Mouse

doi: 10.3390/biomedicines10123146

Figure Lengend Snippet: Components and volume of the PCR reactions.

Article Snippet: Then, we mixed the components and added the appropriate volume of each reaction to each well of an optical plate (catalog number HSS9641, Bio-Rad, Ahracles, CA, United States of America) (48, 96 or 384-well plate, according to available instrument).

Techniques: TaqMan SNP Genotyping Assay

Distribution of  C1QA/C1QB  genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).

Journal: BMC Medical Genetics

Article Title: Association of C1QB gene polymorphism with schizophrenia in Armenian population

doi: 10.1186/1471-2350-12-126

Figure Lengend Snippet: Distribution of C1QA/C1QB genotypes and carriage of minor alleles in patients with schizophrenia (SCZ) and healthy subjects (Controls).

Article Snippet: Genotypes for C1QB rs913243G/T SNP were determined using TaqMan SNP genotyping assay (Applied Biosystems, Assay ID C_3176751_10) according to the manufacturer's instruction.

Techniques:

LD blocks of C1QB gene rs913243/rs291982/rs631090 SNPs and values of absolute D' as well as r 2 for patients with schizophrenia (SCZ) and healthy subjects (Controls) .

Journal: BMC Medical Genetics

Article Title: Association of C1QB gene polymorphism with schizophrenia in Armenian population

doi: 10.1186/1471-2350-12-126

Figure Lengend Snippet: LD blocks of C1QB gene rs913243/rs291982/rs631090 SNPs and values of absolute D' as well as r 2 for patients with schizophrenia (SCZ) and healthy subjects (Controls) .

Article Snippet: Genotypes for C1QB rs913243G/T SNP were determined using TaqMan SNP genotyping assay (Applied Biosystems, Assay ID C_3176751_10) according to the manufacturer's instruction.

Techniques: